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                        <h2>Pandemics In History</h2>
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                    <h2>6 of the Worst Pandemics in History</h2>
                    <p>In late December 2019, the world was introduced to a novel coronavirus—SARS-CoV-2—a pathogen that causes COVID-19.  Just over two months later, the World Health Organization (WHO) declared the coronavirus outbreak a pandemic, meaning the virus had spread across several countries and sickened a large number of people.</p>

<p>Realistically speaking, the next pandemic wasn't a far-fetched idea—in part, because it's already happened multiple times before: "When we talk about another flu pandemic happening, it's not a matter of if, but when," said Dennis Carroll, PhD, director of USAID's Emerging Threats Unit, in the trailer for the Netflix docuseries, Pandemic: How to Prevent an Outbreak. (FYI: Coronavirus is not influenza, though the symptoms may sometimes look similar.)</p>

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                <p>Our extremely interconnected world is largely to blame. “Viruses used to spread at the speed of a steamboat; now they can spread at the speed of a jet. In that sense, we’re more at risk,” infectious disease expert Amesh A. Adalja, MD, senior scholar at the Johns Hopkins Center for Health Security, tells Health.  There are also more densely populated cities now than ever before, Dr. Adalja points out, and that can create an environment that’s ripe for the rapid spread of pandemic diseases. On the flip side, there's a "very sophisticated" healthcare system in place, both in the U.S. and globally, Dr. Adalja says. “We have antivirals, vaccines, and pharmaceutical companies that can develop countermeasures for new emerging diseases,” he says.</p>

<p>In talking about future pandemics, the Netflix series also dives briefly into a few of the worst flu pandemics of the past, particularly the Spanish flu pandemic of 1918. Here's a look at some of the worst pandemics—both flu-related and not, though excluding the current coronavirus pandemic—in modern history.</p>
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                           <p>As per UNDP's 2010 report, India had 2.395 million people living with HIV at the end of 2009, up from 2.27 million in 2008. Adult prevalence also rose from 0.29% in 2008 to 0.31% in 2009.[30] Setting up HIV screening centres was the first step taken by the government to screen its citizens and the blood bank.</p>

<p>The adult HIV prevalence in India is declining from estimated level of 0.41% in 2000 through 0.36% in 2006 to 0.31% in 2009. Adult HIV prevalence at a national level has declined notably in many states, but variations still exist across the states. A decreasing trend is also evident in HIV prevalence among the young population of 15–24 years.</p>

<p>A 2012 report described a need for youth HIV counseling.[31]</p>
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<p>According to NACO data, India has demonstrated an overall reduction of 57 percent in estimated annual new HIV infections (among adult population) from 0.274 million in 2000 to 0.116 million in 2011, and the estimated number of people living with HIV was 2.08 million in 2011.[32][33]</p>

<p>According to NACO, the prevalence of AIDS in India in 2015 was 0.26%, down from 0.41% in 2002;[34] in 2016, it had risen to 0.30%.[3] </p>
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           <h2>Asian Flu (1956-1958)</h2>
           <p>Death Toll: 2 million<br>
Cause: Influenza<br>
Asian Flu was a pandemic outbreak of Influenza A of the H2N2 subtype, that originated in China in 1956 and lasted until 1958. In its two-year spree, Asian Flu traveled from the Chinese province of Guizhou&nbsp;to Singapore, Hong Kong, and the United States. Estimates for the death toll of the Asian Flu vary depending on the source, but the World Health Organization places the final tally at approximately 2 million deaths, 69,800 of those in the US alone.</p>
			<h2>Flu Pandemic (1918)</h2>
            <p>Death Toll: 20 -50 million<br>
Cause: Influenza<br>
Between 1918 and 1920 a disturbingly deadly outbreak of influenza tore across the globe, infecting over a third of the world’s population and ending the lives of 20 – 50 million people. Of the 500 million people infected in the 1918 pandemic, the mortality rate was estimated at 10% to 20%, with up to 25 million deaths in the first 25 weeks alone. What separated the 1918 flu pandemic from other influenza outbreaks was the victims; where influenza had always previously only killed juveniles and the elderly or already weakened patients, it had begun striking down hardy and completely healthy young adults, while leaving children and those with weaker immune systems still alive.</p>
			<h2>Sixth Cholera Pandemic (1910-1911)</h2>
            <p>Death Toll: 800,000+<br>
Cause: Cholera<br>
Like its five previous incarnations, the Sixth Cholera Pandemic originated in India where it killed over 800,000, before spreading to the Middle East, North Africa, Eastern Europe and Russia. The Sixth Cholera Pandemic was also the source of the last American outbreak of Cholera (1910–1911). American health authorities, having learned from the past, quickly sought to isolate the infected, and in the end only 11 deaths occurred in the U.S. By 1923 Cholera cases had been cut down dramatically, although it was still a constant in India.</p>
            <h2>Flu Pandemic (1889-1890)</h2>
            <p>Death Toll: 1 million<br>
Cause: Influenza<br>
Originally the “Asiatic Flu” or “Russian Flu” as it was called, this strain was thought to be an outbreak of the Influenza A virus subtype H2N2, though recent discoveries have instead found the cause to be the Influenza A virus subtype H3N8. The first cases were observed in May 1889 in three separate and distant locations, Bukhara in Central Asia (Turkestan), Athabasca in northwestern Canada, and Greenland. Rapid population growth of the 19th century, specifically in urban areas, only helped the flu spread, and before long the outbreak had spread across the globe. Though it was the first true epidemic in the era of bacteriology and much was learned from it. In the end, the 1889-1890 Flu Pandemic claimed the lives of over a million individuals.</p>
             <h2>Third Cholera Pandemic&nbsp;(1852–1860)</h2>
             <p>Death Toll: 1 million<br>
Cause: Cholera<br>
Generally considered the most deadly of the seven cholera pandemics, the third major outbreak of Cholera in the 19th century lasted from 1852 to 1860. Like the first and second pandemics, the Third Cholera Pandemic originated in India, spreading from the Ganges River Delta before tearing through Asia, Europe, North America and Africa and ending the lives of over a million people. British physician John Snow, while working in a poor area of London, tracked cases of cholera and eventually succeeded in identifying contaminated water as the means of transmission for the disease. Unfortunately the same year as his discovery (1854) went down as the worst year of the pandemic, in which 23,000 people died in Great Britain.</p>
              <h2>The Black Death (1346-1353)</h2>
              <p>Death Toll: 75 – 200 million<br>
Cause: Bubonic Plague<br>
From 1346 to 1353 an outbreak of the Plague ravaged Europe, Africa, and Asia, with an estimated death toll between 75 and 200 million people. Thought to have originated in Asia, the Plague most likely jumped continents via the fleas living on the rats that so frequently lived aboard merchant ships. Ports being major urban centers at the time, were the perfect breeding ground for the rats and fleas, and thus the insidious bacterium flourished, devastating three continents in its wake.</p>
            
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